Explain how mitotic inhibitors and alkylating agents prevent or inhibit the growth of cancer cells.

James, a 3-year-old, has been diagnosed with acute lymphoblastic leukemia and will begin receiving chemotherapy with the mitotic inhibitor teniposide (Vumon) and the alkylating agent cyclophosphamide (Cytoxan) in the morning.

a. Explain how mitotic inhibitors and alkylating agents prevent or inhibit the growth of cancer cells.

b. What special considerations are needed for a child James’ age who will receive chemotherapy?