Explore the available literature to characterize possible ‘Drug-Drug interactions’ that might occur when the following concurrent administration of drugs

Explore the available literature to characterize possible ‘Drug-Drug interactions’ that might occur when the following concurrent administration of drugs. * Indicate clearly if this is pharmacokinetic or pharmacodynamic interaction. Briefly discuss the resultant changes in the pharmacology and therapeutic outcome or toxicity.

* List at least one source of literature where this interaction has been studied in a clinical setting.

* Class is encouraged to refer to the original research articles.

* Mention the number of subjects/patients based on which the conclusions are made.

* Please avoid quoting ‘Case Reports’.

* If you believe no significant interaction exists, justify by providing adequate explanation.

1. Lamotrigine and Oral Contraceptives,

2. Phenytoin and ‘St. John’s wort’,

3. Topiramate and Acetazolamide,

4. Clarithromycin and Carbamazepine,

5. Perampanel and Phenytoin.

Provide primary article references