Discussion Topics, Chapter 24, Antiparkinsonism Agents
1. Mr. Jones has received a diagnosis of Parkinson’s disease and is going to start on the combination drug levodopa/carbidopa (Sinemet) and entacapone (Comtan). Mr. Jones and his wife are nervous and upset by this diagnosis and ask if the medications will cure the disease.
a. How would you explain Parkinson’s disease and the role of medications in treating the disease to this couple?
b. How do levodopa/carbidopa (Sinemet) and entacapone (Comtan) help patients with Parkinson’s disease?
2. Mr. Lin has been on Thioridazine, which is a phenothiazine. He has now developed drug-induced parkinsonism and will be started on biperiden (Akineton). He is very concerned that this new medication will “cause me more problems.”
a. What are the risks of a drug-drug interaction between Thioridazine and biperiden?
b. How will biperiden (Akineton) affect/improve Mr. Lin’s symptoms?